UEFA.com looks at the signs for Tuesday's second legs and finds Bayer 04 Leverkusen have history on their side and Arsenal FC have it all to do at AS Monaco FC.
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Last week Paris Saint-Germain went some way to disproving the theory that teams at home in the second leg of a UEFA Champions League round of 16 tie hold a considerable advantage; now it is the turn of Arsenal FC and Bayer 04 Leverkusen
AS Monaco FC v Arsenal FC (first leg 3-1)
• Arsenal have lost 3-1 at home in the first leg of just one previous UEFA Champions League tie, against FC Bayern München in the 2012/13 round of 16. They won the second leg 2-0 but were knocked out on away goals.
• Monaco have never before won an away first leg 3-1.
• Two teams have won the away first leg 3-1 in the UEFA Champions League round of 16 – and both went on to win the tie (100%).
• In UEFA Champions League knockout rounds, three first legs have finished 3-1 to the away side; all those teams proceeded to win the tie.
• In the UEFA Champions League overall, qualifying included, 21 away sides have triumphed 3-1 in the first leg; again, all prevailed in the tie (100%).
Club Atlético de Madrid v Bayer 04 Leverkusen (first leg 0-1)
• Leverkusen have never before won the home first leg of a UEFA Champions League tie 1-0.
• Atlético have lost only one away first leg 1-0 in the UEFA Champions League era, against FC Schalke 04 in the 2008/09 third qualifying round; they were 4-0 victors in the second leg.
• In the UEFA Champions League round of 16, a first leg has finished 1-0 to the home team on 13 occasions. Of those ties, nine were won by the side who were at home first (69.2%); the remaining four were won by the club who were away first (30.8%).
• In the UEFA Champions League knockout rounds, 15 teams who won the home first leg 1-0 went on to take the tie (75%); five of the sides who were beaten 1-0 away overturned that deficit to progress (25%).
• In the UEFA Champions League overall, qualifying included, 130 first legs have ended 1-0 to the home team. Eighty of those sides went on to win the tie (61.5%) with 50 teams recovering from the 1-0 away defeat to prevail (38.5%).