Club Atlético de Madrid's excellent home form in Europe means that Bayer 04 Leverkusen face a formidable challenge despite their slender first-leg win in Germany.
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Club Atlético de Madrid must achieve something they have managed only twice in UEFA competition to oust Bayer 04 Leverkusen from the UEFA Champions League round of 16 – win a tie after losing the first leg 1-0 away from home.
• Hakan Çalhanoğlu scored the only goal of the first leg in Germany on 25 February, giving Leverkusen their first round of 16 win at the seventh attempt. All six of their previous matches had ended in defeat, with the goal difference 5-22.
• Leverkusen, who qualified as Group D runners-up, have never won a last-16 tie and they will have to work hard to change that statistic against an Atlético side who finished as Group A winners ahead of Juventus.
• The clubs played out two 1-1 draws when they met in the group stage of the 2010/11 UEFA Europa League. Simão's penalty (51) cancelled out an Eren Derdiyok goal (39) in Madrid on 30 September 2010, before substitute Fran Mérida's equaliser (73) negated Patrick Helmes' opener (69) in Leverkusen on 16 December.
• Jupp Heynckes' Leverkusen won the group, with Quique Sánchez Flores’s Atlético, then holders, eliminated after finishing third as a result of that matchday six draw in Germany.
• The lineups in Madrid were:
Atlético: De Gea, Ujfaluši, Álvaro Domínguez, Perea, Filipe Luís, Paulo Assunção, Raúl García (Mérida 46), Reyes, Simão, Forlán (Tiago 46), Costa.
Leverkusen: Adler, Schwaab, Friedrich, Hyypiä, Kadlec, Reinartz, Sam, Vidal (Bender 61), Balitsch (Rolfes 61), Barnetta, Derdiyok (Helmes 68).
• Atlético are looking to reach the quarter-finals of the European Cup for the seventh time.
• The Rojiblancos are chasing a fourth straight home victory in this season's competition having won their three group games in Madrid with a 10-0 aggregate score.
• Atlético have won 20 of their last 22 European matches at the Vicente Calderón. The only defeat was a 2-0 reverse to FC Rubin Kazan in the UEFA Europa League round of 32 in February 2013.
• Gabi, Diego Godín, Juanfran, Koke, Mario Suárez, Miranda and Arda Turan all played when Atlético last hosted German opposition, beating Hannover 96 (2-1) in the quarter-finals of their triumphant 2011/12 UEFA Europa League campaign.
• Atlético's overall home record against Bundesliga clubs is W10 D2 L3.
• Los Colchoneros have won their last five two-legged ties against German sides, their last aggregate defeat coming against 1. FC Dynamo Dresden in the 1979/80 UEFA Cup first round.
• Atlético lost the 1974 European Champion Clubs' Cup final against FC Bayern München, going down 4-0 in a replay after a 1-1 draw.
• The Madrid club have won ten of the 19 UEFA competition ties in which they lost the away first leg, and it is a similar story when that first game ended 0-1: two aggregate Atlético wins, three defeats. The most recent example came against FC Schalke 04 in the 2008/09 UEFA Champions League third qualifying round, when the Spanish side were 4-0 home winners.
• Atlético's shoot-out record in UEFA competition is W0 L3:
6-7 v Derby County FC, 1974/75 UEFA Cup second round
1-3 v ACF Fiorentina, 1989/90 UEFA Cup first round
1-3 v Villarreal CF, 2004 UEFA Intertoto Cup final
• Roger Schmidt's side are hoping to put behind them a run of heavy defeats at this stage of the competition. Although they reached the 2002 final, losing to Real Madrid CF, that was when the tournament had a second group stage. Since the change of format they have lost all three round of 16 ties played:
2013/14 Paris Saint-Germain 1-6 agg
2011/12 FC Barcelona 2-10 agg
2004/05 Liverpool FC 2-6 agg
• Leverkusen's 7-1 loss at Barcelona in the 2011/12 round of 16 was their heaviest European defeat. Bernd Leno, Stefan Reinartz, Simon Rolfes, Lars Bender, Stefan Kiessling, Gonzalo Castro and Ömer Toprak all played.
• Leverkusen returned to Spain last term to beat Real Sociedad de Fútbol 1-0 in the group stage through a Toprak goal. Antoine Griezmann was in the beaten home side.
• The Bundesliga team's overall record in Spain is W3 D2 L9.
• The German club have won all 11 UEFA competition ties in which they were victorious in the home first leg, including three where the initial score was 1-0.
• Leverkusen have lost their last four two-legged ties against Spanish opposition. Their last victory came against RCD Espanyol in the 1988 UEFA Cup final (3-3 agg, 3-2 pens). That remains their only previous shoot-out in UEFA competition.
Coach and player links
• Diego Simeone appeared as a substitute for SS Lazio in two 1-1 draws with Leverkusen in the 1999/2000 first group stage.
• The Argentinian helped FC Internazionale Milano overcome FC Schalke 04 (2-1 agg) in the 1997/98 UEFA Cup quarter-finals en route to winning the trophy.
• Simeone's overall playing record against Bundesliga sides in Europe was W1 D3 L1. That solitary defeat was a home reverse against Borussia Dortmund with Atlético in the 1996/97 UEFA Champions League group stage.
• Emir Spahić faced Atlético four times (D2 L2) during a two-year spell with Sevilla FC (2011–13). In 2012/13 he scored an own goal in a 4-0 Liga loss at the Vicente Calderón, and was then sent off in a 2-1 cup defeat there.
• Spahić's FC Lokomotiv Moskva drew 3-3 with Atlético in the 2007/08 UEFA Cup group stage.
• Arda Turan scored against Spahić's Bosnia and Herzegovina side in a 2-1 win for Turkey in a 2010 FIFA World Cup qualifier.
• In his time in the Bundesliga with VfL Wolfsburg and FC Bayern München, Mario Mandžukić faced Leverkusen six times (W2 D1 L3) and scored three goals.
• Karim Bellarabi and Lars Bender appeared as substitutes in Germany's 1-0 friendly win over Raúl García's Spain in November last year.
• José María Giménez hit the only goal for a Uruguay side also including Godín in a 1-0 friendly win at Son Heung-Min's Korea Republic last September.
• Godín lost the 2010 World Cup third-place play-off with Uruguay against a Germany team that included Stefan Kiessling (2-3).
• Other player links:
Mandžukić with Tin Jedvaj and Dario Krešić (Croatia);
Arda Turan with Toprak and Çalhanoğlu (Turkey).
• Godín and Tiago are suspended; Cristian Ansaldi and Gabi are both a booking away from a ban.
• Atlético, who were four points off Liga top spot in mid-January, have won just five of their last 14 matches in all competitions.
• Atlético dropped to fourth place over the weekend as they were held to a third consecutive league draw on Saturday, 0-0 at RCD Espanyol. Miranda was shown a straight red card on the stroke of half-time.
• Ansaldi was an unused substitute on Saturday after the ankle injury that has kept him out of action since November.
• The Rojiblancos have lost five Liga games this term – one more than in the whole of last season when they won the title.
• Koke, fit after a hamstring injury, marked his first start since January with a goal as Atleti were held 1-1 by Valencia CF on 8 March.
• Saúl Ñiguez is recovering from a blow to the kidney that left him hospitalised after the first leg.
• Fernando Torres has scored three goals – all in the Copa del Rey, against Madrid (2) and FC Barcelona (1) – in 14 appearances since rejoining Atlético on loan.
• Atlético defeated Madrid 4-0 at home on 7 February, completing their first Liga double over the European champions in 64 years. Atlético are unbeaten in six games against their city rivals since the 2014 UEFA Champions League final.
• Spahić and Sebastian Boenisch are both a booking away from a suspension. Ömer Toprak is available after serving a one-game ban following his dismissal against SL Benfica on matchday six.
• Leverkusen are on a five-match winning run, equalling their best run of the season set over the first five games.
• Schmidt's side have gone 480 minutes without conceding, keeping five successive clean sheets (extra time included).
• Wendell scored his first professional goal as Leverkusen won 4-0 at home to VfB Stuttgart on Friday, their biggest victory since November.
• Çalhanoğlu, an ever-present in Leverkusen's starting XI for the first 35 games this season, missed the 3-0 win at SC Paderborn 07 on 8 March due to a knee problem. He was back with 90 minutes on Friday.
• Son's last 11 goals have all come after half-time; he has not scored a first-half goal since 18 October.
• Leverkusen needed extra time to beat second-tier 1. FC Kaiserslautern 2-0 in the German Cup on 3 March. The club – winners of the competition only once, in 1993 – will face Bayern in the quarter-finals on 7 or 8 April.
• Lars Bender has missed the last three games with an ankle injury.
• Robbie Kruse could be out until May with an ankle injury sustained in Australia's Asian Cup final victory over Son's South Korea. Jedvaj has been sidelined by a hamstring injury suffered on 10 January at Leverkusen's winter training camp in Florida.
• Three goals down after 17 minutes against Wolfsburg last month, Leverkusen managed to level at 4-4 thanks to a Son hat-trick. Bas Dost's fourth of the afternoon won it for the visitors in added time.