Real Madrid CF were 6-1 winners in the first leg at FC Schalke 04 and the German side will need to improve on their recent run against Spanish clubs for a second-leg success.
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Having reached the UEFA Champions League quarter-finals in each of the last three seasons, Real Madrid CF will look to continue their progress as FC Schalke 04 visit in the round of 16 second leg.
• Madrid – in the round of 16 for the 11th successive season – were the competition's leading scorers in the group stage with 20 goals. Cristiano Ronaldo contributed nine, a group stage record.
• The German side, who ensured their qualifying place with a matchday six victory, are in the knockout rounds for the second successive season – the first time they have managed that feat.
• Schalke, however, look certain to progress no further after Madrid continued their scoring spree in the first leg, Ronaldo, Gareth Bale and Karim Benzema all scoring twice in a 6-1 success.
• Madrid have lost only twice on the 25 occasions they have hosted German visitors in the Spanish capital, with 19 wins and four draws. Last season they recorded a 2-0 win against Borussia Dortmund in the semi-finals but it was not enough to wipe out a 4-1 first-leg defeat.
• Since FC Bayern München's 1-0 victory at the Santiago Bernabéu in the 2000/01 semi-final – the German club went on to win 3-1 on aggregate – Madrid have won seven and drawn two of their nine games at home to German sides.
• Bayern also won 4-2 at the Bernabéu in the 1999/2000 second group stage and are the only Bundesliga team to have prevailed at the ground. In the 2011/12 semi-final Madrid beat Bayern 2-1 in the home second leg of their UEFA Champions League semi-final but lost the penalty shoot-out that followed.
• Madrid have defeated three German sides in European finals, beating Eintracht Frankfurt 7-3 in the 1960 European Cup and Leverkusen 2-1 in the 2002 UEFA Champions League, both in Glasgow; they also overcame 1. FC Köln 5-3 on aggregate in the 1986 UEFA Cup.
• Madrid's record in two-legged ties with German clubs in UEFA competition is W11 L8.
• The first-leg reverse means Schalke have won only two of their last 14 encounters against Spanish opponents, suffering seven defeats. In 12 away games against Liga clubs their record is W2 D5 L5; they have not won in their last seven games, since a 3-0 victory at RCD Espanyol in the 2005/06 UEFA Cup round of 32.
• The Royal Blues have twice faced Spanish teams in knockout ties in the last four years, beating Valencia CF 3-1 at home after a 1-1 draw away in the 2010/11 UEFA Champions League round of 16 en route to the semi-finals. In the 2011/12 UEFA Cup quarter-finals, Schalke lost 4-2 at home to Athletic Club and then drew 2-2 away.
• Madrid have lost only one of the 28 UEFA competition ties in which they have won the first leg away from home. The sole exception came against Odense BK in the 1994/95 UEFA Cup third round when a 3-2 away success preceded a 2-0 home reverse.
• Schalke have lost all three ties in which they went down at home in the first leg, and avoided defeat in only one of those second legs – the most recent, that 2-2 draw at Athletic Club in 2011/12.
• Ronaldo set the tone for Group B with a matchday one hat-trick as Madrid won 6-1 at Galatasaray AŞ. The Spanish club won all three home games, beating FC København 4-0, Juventus 2-1 and Galatasaray 4-1.
• In Group E Schalke won 1-0 at FC Basel 1893 but then lost 3-0 away to Chelsea FC and shared a goalless draw with FC Steaua Bucureşti.
• Madrid have won 13 – including the last five – and drawn two of their 15 UEFA Champions League home games since a 2-0 defeat by FC Barcelona in the 2010/11 semi-finals. Schalke have lost just two of their last 14 European away fixtures.
• In the 2012/13 last 16, Madrid were held 1-1 at home by Manchester United FC, Ronaldo on target against his former club. The Portuguese scored the decisive goal at Old Trafford after Luka Modrić had cancelled out Sergio Ramos' own goal.
• Schalke lost in last season's round of 16, despite earning a 1-1 draw at Galatasaray. Roman Neustädter was on target in the Gelsenkirchen return, but his team went down 3-2.
• Madrid's shoot-out record in UEFA club competition is:
1-3 v FC Bayern München, 2011/12 UEFA Champions League semi-finals
3-1 v Juventus, 1986/87 European Cup second round
5-6 v FK Crvena zvezda, 1974/75 European Cup Winners' Cup quarter-finals
• Schalke's shoot-out record is:
4-1 v FC Porto, 2007/08 UEFA Champions League round of 16
1-3 v Brøndby IF, 2003/04 UEFA Cup second round
4-5 v SK Slavia Praha, 1998/99 UEFA Cup first round
4-1 v FC Internazionale Milano, 1996/97 UEFA Cup final
• Klaas-Jan Huntelaar, who struck a spectacular first-leg consolation for Schalke, scored eight goals in 20 Liga games for Madrid in 2009.
• Raúl González, the UEFA Champions League's all-time top scorer with 71 goals and a three-time winner of the competition, scored five of those goals in a two-year spell with Schalke after transferring from Madrid in 2010. He had spent 16 years with the Spanish giants.
• Ronaldo scored Portugal's equaliser in a 1-1 friendly draw with Huntelaar's Netherlands at the Estádio Do Algarve on 14 August 2013.
• Timo Hildebrand conceded seven goals in his two games against Madrid while with Valencia in 2007/08, his side losing 5-1 at Mestalla but triumphing 3-2 at the Santiago Bernabéu.
• Kevin-Prince Boateng, Modrić and Gareth Bale all played for Tottenham Hotspur FC between 2008 and 2009, winning the League Cup in 2008.
• Ádám Szalai played for Madrid's reserves between 2007 and January 2010.
• Felipe Santana was part of the Borussia Dortmund side who defeated Madrid in last season's semi-final.
• The injured Sami Khedira has played for Germany alongside Hildebrand, Benedikt Höwedes and Julian Draxler.
• At UEFA EURO 2012 Khedira and Höwedes were in the Germany team that beat Ronaldo, Pepe and Fábio Coentrão's Portugal 1-0 in Lviv.
• Ancelotti's AC Milan beat Schalke at this stage in 2005/06, winning 3-2 at home and drawing 2-2 away.
• Khedira and Hildebrand were team-mates at VfB Stuttgart in 2005/06. Khedira's first two Bundesliga goals came against Schalke in a 3-0 home win on 29 October 2006; he scored 14 goals in 98 league games for Stuttgart.
• Daniel Carvajal faced Schalke twice last season while on Leverkusen's books, winning one and drawing the other. The full-back scored once in 31 Bundesliga appearances.